A hybrid model to test mechanical cues driving cell migration in angiogenesis

Duration: 41 mins 30 secs

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Description:	Angélique, S [CNRS (Centre national de la recherche scientifique)] Tuesday 17th November 2015 - 11:00 to 12:30


Created:	2016-02-17 15:54
Collection:	Coupling Geometric PDEs with Physics for Cell Morphology, Motility and Pattern Formation
Publisher:	Isaac Newton Institute
Copyright:	Angélique, S
Language:	eng (English)


Abstract:	Many studies are stressing the crucial importance of the mechanical component in angiogenesis, but still, very few models really integrate mechanics. We propose to investigate the importance of mechanical cues for cell migration in this context with a new hybrid continuous-discrete model that describes the individual migration of contracting cells on an elastic matrix of fibres. The matrix is described as a continuum whereas the cells are described as discrete elements.

Abstract:

Many studies are stressing the crucial importance of the mechanical component in angiogenesis, but still, very few models really integrate mechanics. We propose to investigate the importance of mechanical cues for cell migration in this context with a new hybrid continuous-discrete model that describes the individual migration of contracting cells on an elastic matrix of fibres. The matrix is described as a continuum whereas the cells are described as discrete elements.

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