Novel imaging agents for detecting cell death
Duration: 2 mins 39 secs
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About this item
| Description: | A team led by Professor Kevin Brindle has developed a novel agent for use in molecular imaging. |
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| Created: | 2011-04-04 16:21 |
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| Collection: | Inventions, IP & Licensing |
| Publisher: | University of Cambridge |
| Copyright: | Cambridge Enterprise |
| Language: | eng (English) |
| Keywords: | cancer; medicine; |
| Abstract: | Prof Brindle and colleagues at the University of Cambridge have developed a series of imaging agents built around a modified 14kDa C2A domain of the protein Synaptotagmin I, which incorporates a specific Ser-Cys mutation. This modified C2A domain retains its ability to bind tightly to phosphatidylserine, which is externalised on the surface of dying (apoptotic) cells. |
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