Cardiac Physiome Project

Cardiac Physiome Project's image
Created: 2009-07-22 15:47
Institution: Isaac Newton Institute for Mathematical Sciences
Description: Predicting physiological behaviour from experimental data combined with environmental influences is a compelling, but unfulfilled, goal of post-genomic biology. This undeniably ambitious goal is the aim of the Physiome Project and its subset the Cardiome Project which is an international effort to build a biophysically based multi-scale mathematical model of the heart. To achieve this goal requires further development of the current generation of advanced cardiac models which span an already diverse set of mathematical representations from stochastic sub-cellular regulation models to whole-organ-based sets of coupled partial differential equations. The focus of this programme will be on the development and application of the mathematical techniques which underpin the ongoing extension of this approach, and specifically to:

* integrate data from disparate sources into a common quantitative framework;
* examine the complex cause and effect relationships which exist across many temporal and spatial orders of magnitude in physiology;
* determine the appropriate level of detail to capture observable phenomena and the closely related issue of parameter identifiability;
* examine issues of model inheritance and multi-scale coupling for combining existing models together to create extended frameworks;
* define standards for the constituent electrical, mechanical and vascular classes of cardiac models.

Read more at: www.newton.ac.uk/programmes/CPP/
 

Media items

This collection contains 56 media items.

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Media items

3D/1D geometrical multiscale modeling of vascular networks

   805 views

Passerini, T (Emory)
Tuesday 21 July 2009, 10:45-11:00

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


A novel approach to multidomain modeling of electrical conduction in cardiac tissue

   788 views

Sachse, F (Utah)
Monday 20 July 2009, 16:15-16:30

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


A posteriori error estimation and adaptivity for operator decomposition methods

   406 views

Tavener, S (Colorado State)
Tuesday 21 July 2009, 14:15-14:30

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Thu 23 Jul 2009


Adaptive Tetrahedral Meshing for Personalized Cardiac Simulations

   666 views

Delingette, H (INRIA)
Thursday 23 July 2009, 14:45-15:00

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Mon 27 Jul 2009


Building detailed cardiac electrophysiological models from high-resolution images

   605 views

Grau, V (Oxford)
Wednesday 22 July 2009, 10:45-11:00

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Fri 24 Jul 2009


Building tissue mechanics into novel types of multi-scale models

   685 views

Jensen, O (Nottingham)
Friday 24 July 2009, 10:15-10:30

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 29 Jul 2009


CellML language and tools supporting the cardiac physiome

   487 views

Nielsen, P (Auckland)
Friday 24 July 2009, 10:45-11:00

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 29 Jul 2009


Clinically observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism

   623 views

Beard, D (Medical College of Wisconsin)
Monday 20 July 2009, 12:15-12:30

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


Closing comments

   591 views

Smith, N (Oxford)
Friday 24 July 2009, 11:45-12:00

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 29 Jul 2009


Commented Poster Session 1

   405 views

Commented Posters at the The Cardiac Physiome: Multi-scale and Multi-physics Mathematical Modelling Applied to the Heart conference.

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


Commented Poster Session 2

   404 views

Commented Posters at the The Cardiac Physiome: Multi-scale and Multi-physics Mathematical Modelling Applied to the Heart conference.

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Fri 24 Jul 2009


Computational modelling to investigate the role of aging and species on arterial branch lesion patterns

   1,083 views

Sherwin, S (Imperial College London)
Wednesday 22 July 2009, 13:45-14:00

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Thu 21 Jan 2010


Connexins, buffers and mitochondria: novel pH/Ca2+ regulators in heart

   699 views

Vaughan-Jones, R (Oxford)
Monday 20 July 2009, 10:00-10:45

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


Development and testing of Cardiac Physiome cell model parts in skeletal muscle

   418 views

Jeneson, J (TU, Eindhoven)
Monday 20 July 2009, 12:00-12:15

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


Development of a virtual heart - Part l

   885 views

Boyett, M (Manchester)
Monday 20 July 2009, 14:30-14:45

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


Development of a virtual heart - Part ll

   700 views

Zhang, H (Manchester)
Monday 20 July 2009, 14:45-15:00

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


Dynamic modelling of chorded mitral valve

   553 views

Luo, X (Glasgow)
Wednesday 22 July 2009, 14:30-14:45

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Fri 24 Jul 2009


Electrophysiological metric and geometry of the heart

   884 views

Panfilov, S (Utrecht)
Monday 20 July 2009, 15:30-15:45

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Wed 22 Jul 2009


Fluid solid interaction for vascular applications

   747 views

Hose, R (Sheffield)
Wednesday 22 July 2009, 13:30-13:45

Collection: Cardiac Physiome Project

Institution: Isaac Newton Institute for Mathematical Sciences

Created: Fri 24 Jul 2009


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