Industrial and Clinical Application of Cardiac Simulations: Quantifying Uncertainty in Model Predictions
Created: | 2019-06-04 17:22 |
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Institution: | Isaac Newton Institute for Mathematical Sciences |
Description: | Background
The function of the heart can be simulated using multi-scale computational models: ranging from representations of electrical activation and force generation in a single cell; up to anatomical models of an individual patient’s whole heart and cardiovascular system. There are a range of industrial and clinical applications of cardiac simulations that have begun to be tested and used in the last few years including assessing the safety of new drugs and providing patient-specific guidance for clinical procedures. A major obstacle to progress is that the present generation of cardiac simulations do not account fully for all the uncertainties and variabilities that we know to be present. Our uncertainties include geometry from incomplete medical images, and properties taken from the noisy data that are typically available. These lead to uncertainties around the inputs, meshes, parameters, and even equations/structure, that we use within the models. Variability between individual cells, tissues, organs and the bodies that they lie within are also considerable and accounting for this may be crucial in predicting clinical outcomes. Aims and Objectives This knowledge exchange event by the Newton Gateway to Mathematics takes place as part of the INI Research Programme on the Fickle Heart – within the workshop on Uncertainty Quantification for Cardiovascular Simulations. This particular event will open up the discussion to a wider audience, including those working in biotechnology, healthcare, pharmaceuticals and the public sector. The introductory talks will highlight the key issues raised during the Research Programme and suggest some next steps. A number of end-user talks from industry and the public sector will describe how organisations manage the uncertainty of modelling and the challenges they face. The main aims of the day will be to: Discuss the latest developments in considering uncertainty and variability in cardiac simulation. Understand challenges faced by industry and the healthcare sector in their applications of cardiac modelling. Form an interdisciplinary community of researchers interested in the mathematics of uncertainty quantification, the creation and solution of biophysical models of the heart and cardiovascular system, and their translation into industrial and clinical applications. |
Media items
This collection contains 7 media items.
Media items
Clinical Applications of Cardiac Models
Niederer, S
Tuesday 4th June 2019 - 10:30 to 10:55
Collection: Industrial and Clinical Application of Cardiac Simulations: Quantifying Uncertainty in Model Predictions
Institution: Isaac Newton Institute for Mathematical Sciences
Created: Wed 5 Jun 2019
From Medical Images to Digital Twins: Technological and Translational Challenges
Passerini, T
Tuesday 4th June 2019 - 12:05 to 12:30
Collection: Industrial and Clinical Application of Cardiac Simulations: Quantifying Uncertainty in Model Predictions
Institution: Isaac Newton Institute for Mathematical Sciences
Created: Wed 5 Jun 2019
Modelling and Simulation for Medical Devices: When Can we Trust a Computational Model?
Pathmanathan, P
Tuesday 4th June 2019 - 11:40 to 12:05
Collection: Industrial and Clinical Application of Cardiac Simulations: Quantifying Uncertainty in Model Predictions
Institution: Isaac Newton Institute for Mathematical Sciences
Created: Wed 5 Jun 2019
Numerical Solution Methods for the Heart and the Circulation
Quarteroni, A
Tuesday 4th June 2019 - 12:30 to 12:55
Collection: Industrial and Clinical Application of Cardiac Simulations: Quantifying Uncertainty in Model Predictions
Institution: Isaac Newton Institute for Mathematical Sciences
Created: Wed 5 Jun 2019
Pharmacokinetic-Pharmacodynamic Modelling to Translate Cardiovascular Pharmacology from Preclinical Findings to the...
van der Graaf, P
Tuesday 4th June 2019 - 16:20 to 16:45
Collection: Industrial and Clinical Application of Cardiac Simulations: Quantifying Uncertainty in Model Predictions
Institution: Isaac Newton Institute for Mathematical Sciences
Created: Wed 5 Jun 2019
Sensitivity and Uncertainty Analysis for Cardiac Cell Models
Clayton, R
Tuesday 4th June 2019 - 15:30 to 15:55
Collection: Industrial and Clinical Application of Cardiac Simulations: Quantifying Uncertainty in Model Predictions
Institution: Isaac Newton Institute for Mathematical Sciences
Created: Wed 5 Jun 2019
The Living Heart Project: Development of Multi-scale Computational Heart Models with Applications in Individualised...
Davies-Taylor, C
Tuesday 4th June 2019 - 14:20 to 14:45
Collection: Industrial and Clinical Application of Cardiac Simulations: Quantifying Uncertainty in Model Predictions
Institution: Isaac Newton Institute for Mathematical Sciences
Created: Wed 5 Jun 2019