Designs for dose-escalation trials
Duration: 32 mins 31 secs
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About this item
| Description: |
Bailey, R (University of St Andrews)
Wednesday 8th July 2015, 12:00 - 12:30 |
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| Created: | 2015-07-13 12:42 |
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| Collection: | Design and Analysis of Experiments |
| Publisher: | Isaac Newton Institute |
| Copyright: | Bailey, R |
| Language: | eng (English) |
| Abstract: | For First-in-Human trials of a new drug, healthy volunteers are recruited in cohorts. For safety reasons, only the lowest dose and placebo may be used in the first cohort, and no new planned dose may be used until the one immediately below has been used in a previous cohort. How should doses be allocated to cohorts? |
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