Construction of efficient experimental designs under resource constraints

27 mins 13 secs, 49.78 MB, MP3 44100 Hz, 249.73 kbits/sec

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Description:	Harman, R (Comenius University) Wednesday 8th July 2015, 11:30 - 12:00


Created:	2015-07-13 12:31
Collection:	Design and Analysis of Experiments
Publisher:	Isaac Newton Institute
Copyright:	Harman, R
Language:	eng (English)


Abstract:	We will introduce "resource constraints" as a general concept that covers many practical restrictions on experimental design, such as limits on budget, time, or available material. To compute optimal or near-optimal exact designs of experiments under multiple resource constraints, we will propose a tabu search heuristic related to the Detmax procedure. To illustrate the scope and performance of the proposed algorithm, we chose the problem of construction of optimal experimental designs for dose escalation studies.

Abstract:

We will introduce "resource constraints" as a general concept that covers many practical restrictions on experimental design, such as limits on budget, time, or available material. To compute optimal or near-optimal exact designs of experiments under multiple resource constraints, we will propose a tabu search heuristic related to the Detmax procedure. To illustrate the scope and performance of the proposed algorithm, we chose the problem of construction of optimal experimental designs for dose escalation studies.

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