Modeling and stochastic analysis of autoregulation of the Krox20 transcription factor driving cellular diversification and hindbrain patterning
52 mins 23 secs,
750.61 MB,
MPEG-4 Video
640x360,
29.97 fps,
44100 Hz,
1.91 Mbits/sec
Share this media item:
Embed this media item:
Embed this media item:
About this item
| Description: |
Reingruber, J
Tuesday 17th May 2016 - 15:00 to 16:00 |
|---|
| Created: | 2016-06-01 13:03 |
|---|---|
| Collection: | Stochastic Dynamical Systems in Biology: Numerical Methods and Applications |
| Publisher: | Isaac Newton Institute |
| Copyright: | Reingruber, J |
| Language: | eng (English) |
| Abstract: | I will present the molecular implementation and function of the autoregulatory loop that amplifies and maintains the expression of Krox20, a transcription factor governing vertebrate hindbrain segmentation. By combining data analysis, biophysical modeling, stochastic analysis and simulations, I dissect the autoregulation process as a function of an initiation signal that leads to promoter activation and subsequent mRNA and protein production. Autoregulation generates a bistable switch that turns a transient initiation signal into a persistent cell fate. The duration and strength of the input signal controls patterning by modulating the distribution between the cell fates. |
|---|---|
Available Formats
| Format | Quality | Bitrate | Size | |||
|---|---|---|---|---|---|---|
| MPEG-4 Video * | 640x360 | 1.91 Mbits/sec | 750.61 MB | View | Download | |
| WebM | 640x360 | 644.22 kbits/sec | 247.25 MB | View | Download | |
| iPod Video | 480x270 | 490.11 kbits/sec | 188.04 MB | View | Download | |
| MP3 | 44100 Hz | 249.78 kbits/sec | 95.92 MB | Listen | Download | |
| Auto | (Allows browser to choose a format it supports) | |||||