Modelling protein evolution
57 mins 35 secs,
364.40 MB,
WebM
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About this item
| Description: |
Gascuel, O (CNRS)
Wednesday 22 June 2011, 14:00-15:00 |
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| Created: | 2011-06-27 09:41 | ||||
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| Collection: | Phylogenetics | ||||
| Publisher: | Isaac Newton Institute | ||||
| Copyright: | Gascuel, O | ||||
| Language: | eng (English) | ||||
| Credits: |
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| Abstract: | I'll describe our recent efforts to model protein evolution and amino-acid substitutions by (1) designing an easy to use pipeline to estimate amino-acid replacement matrices for specific protein groups, (2) using the protein structure, (3) simplifying mixture models that have been proposed so far. I'll discuss several issues related to models (e.g. complexity trade-off), biology (e.g. independence of nucleotide mutations) and theory (e.g. identifiability, prediction of ancestral sequences). |
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